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Iris Valera-Larios about ITP blood disorder treatments : What are platelets? There are three types of blood cell which are all formed in the bone marrow; red cells, white cells and platelets. Platelets, which are small and sticky and circulate in the bloodstream provide the inital plug to stop bruising and bleeding after an injury, and stop blood leaking from capilleries. A blood sample is taken to measure the circulating platelets, and in most people there are between 150,000 and 400,000 platelets in every cubic millimetre of blood. However in the USA we simplify this by describing a platelet count of, say, 150 rather than 150,000. Anyone with a count less than 100 would be considered thrombocytopenic (ie. short of platelets).
What is ITP? Immune thrombocytopenia (formerly known as idiopathic thrombocytopenic purpura) is a medical term for an autoimmune disorder (immune) causing a shortage of platelets (thrombocytopenia) and bruising (purpura). What is the cause of ITP? ITP is an autoimmune disease in which the immune system mistakes the platelets as being foreign and destroys them. It can follow a virus, vaccination or certain medications, but for most people the cause is unknown.
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You should avoid drugs like aspirin and non-steroidal anti-inflammatory drugs (e.g. ibuprofen, diclofenac) when your platelets are below 50 × 10^9/l because of a greater risk that gastric irritation could lead to bleeding. Also discuss any planned surgery or dental procedure with your haematologist (as well as informing the dentist or surgeon) so that a plan can be made. When to seek help If you have minor bleeding symptoms such as nose bleeds or bleeding in the mouth please ask your GP to carry out an urgent full blood count, or contact the haematology department. A purple rash called purpura (often on the lower legs) which does not fade when you press it may be a sign of a low platelet count.
How is idiopathic thrombocytopenic purpura treated? Specific treatment for idiopathic thrombocytopenic purpura will be determined by your health care provider based on: Your age, overall health, and medical history; Extent of the disease; Your tolerance for specific medications, procedures, or therapies; Expectations for the course of the disease; Your opinion or preference. When treatment is necessary, the two most common forms of immediate treatment are steroids and intravenous gamma globulin. See even more info at Iris Valera-Larios.
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What are the symptoms of idiopathic thrombocytopenic purpura? Normal platelet count is in the range of 150,000 to 450,000. With ITP, the platelet count is less than 100,000. By the time significant bleeding occurs, you may have a platelet count of less than 10,000. The lower the platelet count, the greater the risk of bleeding. Because platelets help stop bleeding, the symptoms of ITP are related to increased bleeding. However, each person may experience symptoms differently.