To alleviate suffering & improve the quality of life of patients with incurable or intractable disorders & injury of the nervous system, by restoring functional abilities to a maximum possible, by extending a professional, holistic & caring manner, and to conduct basic & clinical research by constant work on innovation & development, so that the best therapeutic strategies can be evolved.
In the past donated organs were transplanted to replace the diseased or failed organs in the recipients. Soon the number of recipients exceeded the number of donated. To overcome this demand, cell therapy offered the possibility of replacement of the damaged cells of tissue with new cells. Stem cell infusion helps to treat a plethora of conditions including cerebral palsy, spinal cord injury, intellectual disability, and other neurodegenerative syndromes as well.
Stem cells have the potential to develop into different cells of the tissues (of the body) and the ability of self-renewal. When serving as a repair system, the stem cells divide without limit as long as the person is alive. As they divide, they remain as stem cells or develop into cells with more specialized functions, like a brain cell or a muscle cell.
Stem cells, from different sources, have three common properties: They can divide and replicate themselves as long as the person is alive.
Impairments linked to neuromuscular conditions are usually irreversible due to inadequate cell regeneration or impaired cells in the central nervous system. It was observed that the cellular characteristics of autologous stem cells had the capability of treating major neurological disorders without incurring any side effects. With their neurotrophic properties, self-renewal & differentiation capacity, and immune modulation effects, the bone marrow-derived stem cells are considered as a promising candidate for treating disorders related to the nervous system.
For cell treatment, bone marrow derived mesenchymal stem cells are isolated from the marrow tissue (extracted from the patient’s hip bone) in an expedited, painless and safe way. By centrifugation procedure, a sufficient number of stem cells are separated from the unwanted tissue within a few hours. These injectable stem cells are infused intrathecally into the spinal area or the damaged muscle points, as per the need of the patients.
These bone marrow-derived stem cells have many useful properties that lead to great clinical improvement in post-cell-based therapy. According to various clinical trials, treatment with bone marrow derived mesenchymal stem cells have shown improvement in patients with traumatic brain injury, spinal cord injury and other neurological disorders through axonal sprouting and remyelination, potential to replace/protect the damaged neurons/cells, and neovascularization.
How do the infused stem cells act? Once infused into the body,
– The infused stem cells journey toward the nervous system and blend into the neural circuits to mend or improve the disrupted synaptic transmission.
– Post infusion, improved neuropathological condition, upregulated Aß clearance and reduced deposition is detected within a short period.
– The infused stem cells reduce neuroinflammation and provide protective immunomodulatory effect.
– The stem cells secrete neurotrophic influence and nerve growth factors, bringing cognitive and memory improvement in patients.
Apart from encouraging effects, renewed brain plasticity is also observed in patients following intrathecal delivery of stem cells. With the new medical breakthrough in stem cell therapy, the treatment has become a highly sought-after curative. To know about the treatment efficacy, one must understand the efficiency of stem cells in terms of engraftment, migration, cytokines and growth factors. However, cell-based therapy is a promising contribution to regenerative medicine and has gained considerable clinical attention. See extra info at NeuroGen Hospital.
Knowing the Specialists: Managing all aspects of a child’s unique diagnosis is essential for successful comprehensive treatment. Well-rounded treatment approaches require a team of multidisciplinary specialists, usually with a pediatrician at the center of the group. Pediatricians are generalists who manage the treatment plan, recognize specific issues and recommend specialists who can treat those issues. Each specialist uses ongoing treatment and assessments to ensure that all areas of the child’s development are proceeding as normally as possible. Scoliosis (spinal curvature) and shortened achilles tendons are some specific movement and posture issues that are treated with physical therapy. Physical therapy is an important prevention measure, as these issues can get worse over time. Proper treatment of the above conditions can also improve the chance of a child walking independently.
A few tips to help your child with autism: The earlier children with autism spectrum disorder get help, the greater their chance of treatment success. Early intervention is the most effective way to speed up your child’s development and reduce the symptoms of autism over the lifespan. Learn about autism. The more you know about autism spectrum disorder, the better equipped you’ll be to make informed decisions for your child. Educate yourself about the treatment options, ask questions, and participate in all treatment decisions. Become an expert on your child. Figure out what triggers your kid’s challenging or disruptive behaviors and what elicits a positive response. What does your child find stressful or frightening? Calming? Uncomfortable? Enjoyable? If you understand what affects your child, you’ll be better at troubleshooting problems and preventing or modifying situations that cause difficulties.
The spinal cord is responsible for sending messages from the brain to all parts of the body. It also sends messages from the body to the brain. We’re able to perceive pain and move our limbs because of messages sent through the spinal cord. If the spinal cord sustains an injury, some or all of these impulses may not be able to “get through.” The result is a complete or total loss of sensation and mobility below the injury. A spinal cord injury closer to the neck will typically cause paralysis throughout a larger part of the body than one in the lower back area.
Stem Cells: So far, umbilical cord blood has been successfully used in the treatment of over 75 conditions, such as various types of cancer, blood disease and immune deficiencies, such as leukemia, sickle cell anemia (siclemia), thalassemia, Hodgkin’s disease and non-Hodgkin’s lymphoma. Stem cells also treat very rare, potentially fatal conditions, such as Krabbe’s disease or Sanfilippo’s syndrome. But from year to year new diseases appear on the list of 75 that can be treated with the help of stem cells.
Muscular Dystrophy encompasses a group of genetic disorders which are characterised by progressive loss of muscle mass and subsequent weakness. Dystrophy is coined from the Greek word which essentially means ‘bad nourishment’. Early detection of muscular dystrophy started with a study by Sir Charles Bell, on the increasing weakness of the muscles of young boys, in 1830. This study on Muscular Dystrophy talks about a set of less than 30 genetic diseases that can lead to an alarming rate of increasing weakness of skeletal muscles applied through all voluntary movements. All these different ailments differ through the arrival stage, seriousness and prototype of muscles that are affected. All the manifestations of muscular dystrophy worsens as the muscles continually deteriorates and starts to weaken, and hence, it is considered as a “progressive muscular disorder”. See more info Muscular Dystrophy Stem Cell Treatment.